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转基因作物伤害动物内脏（论文全文）
直言了，2010-04-01。


本人在和讯日志介绍了关于转基因作物伤害内脏的论文后，反馈颇为积极，许多人再次体会到事物总是多面的，转基因技术也如此，即：一些利益官员媒体只说转基因作物的效益而不说风险，那推销做法既不是诚实商业广告，更不是科学发展观、更不是国家法规政策所允许的。

该论文发表于国际生物学刊（2009-12-10），作者是法国科研人员。他们的论文说明：经过足够样本和多方面比较，发现转基因玉米对老鼠内脏发生毒性副作用，作用程度跟食用数量时间和对象性别等因素相关。跟2004年以来陆续发表的调查报告一样，这个实验也打破了所谓转基因食品作物是安全的神话。该实验报告还比较分析了孟山都公司提供的转基因作物喂养老鼠的实验数据，指明该数据存在足够严重的方法问题和不完整等问题。

据介绍，该国际生物学刊为纯学术刊物，编委会由中欧美澳等国的生物学、基因学和医学等相关学科的专业学者组成；诺贝尔科学奖获得者、分子遗传学转家马里奥·卡佩奇等三位美国国家科学院院士（包括中国科学家陈竺）入盟为编委成员。作者要发表论文，需要如实说明自己与论文内容是否有利益冲突；若有，或难以发表、或其学术价值可能大打折扣，即：该刊物是按照美国英国等政府卫生部门的学术刊物标准为经营原则的 （在美国等西方发达国家，某学术刊物对作者与论文内容是否有利益冲突的要求，往往是判断该杂志公正性的重要尺度之一）。

之后不久，美国联邦政府卫生部也发表了该论文。此时此刻，正是美国联邦法院决定介入相关部门、审查孟山都公司转基因作物种植申请报告是否存在“自己审批自己”的行为和数据提供是否符合法规要求等问题。

到昨天为止，简单查询看，有大约11,200个英文网站或网页从该杂志或从美国卫生部转载了该论文，可见关注程度之大之广。

应一些读者网友来信要求，本人征得该刊物同意，在这里转载论文全文。

论文标题：A Comparison of the Effects of Three GM Corn Varieties on Mammalian Health.。
发表刊物：Int J Biol Sci 2009; 5:706-726, Ivyspring International Publisher.
发表时间：Received 2009-7-23 /Accepted 2009-11-17 /Published 2009-12-10 .
连接地址： / 。

美国卫生部发表地址连接：
PMID: 20011136 [PubMed - indexed for MEDLINE]/PMCID: PMC2793308,
U.S. National Library of Medicine /National Institutes of Health,
..


论文原文全文：
 

A Comparison of the Effects of Three GM Corn Varieties on Mammalian Health

A Comparison of the Effects of Three GM Corn Varieties on Mammalian Health

Joël Spiroux de Vendômois1, François Roullier1, Dominique Cellier1,2, Gilles-Eric Séralini1,3

1. CRIIGEN, 40 rue Monceau, 75008 Paris, France
2. University of Rouen LITIS EA 4108, 76821 Mont-Saint-Aignan, France
3. University of Caen, Institute of Biology, Risk Pole CNRS, EA 2608, 14032 Caen, France
 

How to cite this article:
de Vendômois JS, Roullier F, Cellier D, Séralini GE. A Comparison of the Effects of Three GM Corn Varieties on Mammalian Health. Int J Biol Sci 2009; 5:706-726. Available from

Abstract

We present for the first time a comparative analysis of blood and organ system data from trials with rats fed three main commercialized genetically modified (GM) maize (NK 603, MON 810, MON 863), which are present in food and feed in the world.  NK 603 has been modified to be tolerant to the broad spectrum herbicide Roundup and thus contains residues of this formulation. MON 810 and MON 863 are engineered to synthesize two different Bt toxins used as insecticides. Approximately 60 different biochemical parameters were classified per organ and measured in serum and urine after 5 and 14 weeks of feeding. GM maize-fed rats were compared first to their respective isogenic or parental non-GM equivalent control groups. This was followed by comparison to six reference groups, which had consumed various other non-GM maize varieties. We applied nonparametric methods, including multiple pairwise comparisons with a False Discovery Rate approach. Principal Component Analysis allowed the investigation of scattering of different factors (sex, weeks of feeding, diet, dose and group). Our analysis clearly reveals for the 3 GMOs new side effects linked with GM maize consumption, which were sex- and often dose-dependent. Effects were mostly associated with the kidney and liver, the dietary detoxifying organs, although different between the 3 GMOs. Other effects were also noticed in the heart, adrenal glands, spleen and haematopoietic system. We conclude that these data highlight signs of hepatorenal toxicity, possibly due to the new pesticides specific to each GM corn. In addition, unintended direct or indirect metabolic consequences of the genetic modification cannot be excluded.

Keywords: GMO, toxicity, GM corn, rat, NK 603, MON 810, MON 863 .